Range of antinuclear antibodies in “healthy” individuals

Anticardiolipin and antinuclear antibodies in the adult healthy Omani individuals.

OBJECTIVE To investigate the prevalence and normal versus abnormal levels of anticardiolipin antibodies (aCL) in a healthy adult population of Omanis and whether a correlation exists between aCL and antinuclear antibodies (ANA) in this Omani population. METHODS A total of 521 healthy Omani individuals (333 males and 188 females), aged between 17-54-years were investigated for the presence and...

Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?

Antinuclear antibodies (ANAs) are venerable biomarkers for assessing the diagnosis and prognosis of patients with autoimmunity. While closely associated with diseases such as systemic lupus erythematosus, ANA expression occurs commonly in healthy people. The basis for this expression is unknown, although it may reflect features of the assays for antibody detection or intrinsic immunological dis...

Antinuclear Antibodies

knowledge of gene regulation, particularly in neoplastic cells, this deficit is striking. With our current understanding of chromosomal translocations, point mutations, and gene amplification in tumor cells, it is surprising to read that there is ". . . no difference between cancer and normal DNA . . ." (p. 130). The author spends a fair amount of time discussing possible mechanisms for the car...

Antinuclear antibodies in systemic sclerosis

Antinuclear antibodies in rosacea patients

INTRODUCTION Rosacea is a common inflammatory disorder, characterized by a spectrum of facial manifestations. The clinical similarity to other dermatoses, like lupus erythematosus, might lead to misdiagnosis, particularly in patients with elevated antinuclear antibody titers. AIM To assess the frequency, titer and specificity of antinuclear antibodies in rosacea patients and correlate these f...